中医药修复肠道屏障治疗溃疡性结肠炎研究进展*

作者：贾飞亮1，杨会举2，孙晓燠1，郭怡晗1

单位：1.河南中医药大学针灸推拿学院，河南 郑州 450046； 2.河南中医药大学第三附属医院，河南 郑州 450003

引用：引用：贾飞亮，杨会举，孙晓燠，郭怡晗.中医药修复肠道屏障治疗溃疡性结肠炎研究进展[J].中医药导报,2026,32(3):140-146,223.

DOI：10.13862/j.cn43-1446/r.2026.03.022

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摘要：基于肠道屏障总结中医药治疗溃疡性结肠炎（UC）的机制，以期为临床治疗UC提供更多思路。中医药能通过促进肠上皮细胞增殖、迁移与修复，调节紧密连接蛋白表达与功能，减轻氧化应激，促进黏蛋白（MUC）表达，增强杯状细胞活性，增加黏液分泌厚度与连续性，保护肠道屏障的完整性，从而减少炎症对结肠的损伤。中医药还可以通过降低辅助性T细胞17（Th17）/调节性T细胞（Treg）比值，促进促炎巨噬细胞（M1）向促消退巨噬细胞（M2）转化，抑制核因子κB（NF-κB）/Janus激酶（JAK)-信号转导与转录激活因子（STAT）/NOD样受体热蛋白结构域相关蛋白3（NLRP3）等炎症通路，调节肠道菌群及其代谢产物，调控宿主肠道炎症及黏膜免疫，从而治疗UC。

关键词：溃疡性结肠炎；肠道屏障；作用机制；中医药；综述

Abstract：

Based on the intestinal barrier, this article summarizes the mechanisms of traditional Chinese medicine (TCM) in treating ulcerative colitis (UC), aiming to provide more insights for clinical management. TCM can protect the integrity of the intestinal barrier and reduce inflammatory damage to the colon by promoting the proliferation, migration, and repair of intestinal epithelial cells; regulating the expression and function of tight junction proteins; alleviating oxidative stress; promoting mucin (MUC) expression; enhancing goblet cell activity; and increasing the thickness and continuity of mucus secretion. Furthermore, TCM treats UC by reducing the Th17/Treg ratio, promoting the conversion of pro-inflammatory macrophages (M1) to pro-resolving macrophages (M2), inhibiting inflammatory pathways such as NF-κB, JAK-STAT, and NLRP3, and modulating the gut microbiota and its metabolites, thereby regulating host intestinal inflammation and mucosal immunity.

Key words：ulcerative colitis; intestinal barrier; mechanism of action; traditional Chinese medicine; review

发布时间：2026-03-28

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