基于脂代谢重编程的中药防治肝癌作用机制研究进展*

作者：刘雨茜1，郑灼熔1，王教智1，王紫妍2，龙九妹3，周 敏3，张咪娜3，胡 琦1

单位：1.湖南中医药大学中西医结合学院，湖南 长沙 410208； 2.湖南中医药大学药学院，湖南 长沙 410208； 3.湖南中医药大学针灸推拿与康复学院，湖南 长沙 410208

引用：引用：刘雨茜，郑灼熔，王教智，王紫妍，龙九妹，周敏，张咪娜，胡琦.基于脂代谢重编程的中药防治肝癌作用机制研究进展[J].中医药导报,2026,32(3):98-105.

DOI：10.13862/j.cn43-1446/r.2026.03.017

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摘要：

肝癌是一种常见的由代谢重编程驱动、脂质异常代谢介导的肝脏恶性肿瘤性疾病。脂代谢重编程失衡是诱导肝癌发生发展的重要机制，主要包括脂肪酸氧化紊乱、胆固醇合成异常、磷脂代谢失调等方面。大量研究显示，中医药可通过多角度、多通路调节脂代谢重编程，进而影响肿瘤细胞的增殖、转移能力及肿瘤微环境，能较好地改善肝癌患者的临床症状。调节脂代谢重编程可以维持肝细胞代谢稳态，阻断异常能量供应途径，控制肝癌的发生发展。

关键词：脂代谢重编程；肝癌；中药；作用机制；综述

Abstract：

Hepatocellular carcinoma (HCC) is a common malignant liver tumor driven by metabolic reprogramming and mediated by abnormal lipid metabolism. Dysregulation of lipid metabolism reprogramming is a crucial mechanism inducing the occurrence and development of HCC, primarily including disorders in fatty acid oxidation, abnormal cholesterol synthesis, and phospholipid metabolism disorder. Numerous studies have shown that traditional Chinese medicine (TCM) can regulate lipid metabolism reprogramming through multiple pathways and targets, thereby affecting tumor cell proliferation, metastatic ability, and the tumor microenvironment, which can significantly improve the clinical symptoms of HCC patients. Regulating lipid metabolism reprogramming can maintain hepatocyte metabolic homeostasis, block abnormal energy supply pathways, and control the occurrence and progression of HCC.

Key words：lipid metabolism reprogramming; hepatocellular carcinoma; traditional Chinese medicine; mechanism of action; review

发布时间：2026-03-28

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