基于数据挖掘探析林洪生“固本清源”法治疗肺癌术后患者的用药规律*

作者：韩宝瑾，刘 杰，毛启远，蔡瑞娟，谭 滢，钟毅薇，林洪生

单位：中国中医科学院广安门医院，北京 100053

引用：引用：韩宝瑾，刘杰，毛启远，蔡瑞娟，谭滢，钟毅薇，林洪生.基于数据挖掘探析林洪生“固本清源”法治疗肺癌术后患者的用药规律[J].中医药导报,2025,31(12):222-228.

DOI：10.13862/j.cn43-1446/r.2025.12.036

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摘要：目的：探析林洪生采用“固本清源”法辨治肺癌术后患者的用药规律。方法：收集林洪生2008年1月1日至2025年3月15日在中国中医科学院广安门医院门诊治疗的肺癌术后1年内的患者医案资料，运用古今医案云平台网站对处方进行高频药物、中药性能以及多味药关联性用药的规律研究。结果：共纳入肺癌术后患者151例，眠差（181次，53.1%）、咳嗽（176次，51.6%）、气短（137次，40.2%）、乏力（126次，36.9%）、出汗（92次，27.0%）是肺癌患者术后1年内发生频率最高的症状。本研究共涉及341诊次处方、116味中药、总频数为6 038次。高频药物为红景天、白术、天冬、金荞麦等，药物功效多为补虚、清热等；结合关联规则、聚类分析和复杂网络分析得出“黄芪-防风-白术-天冬-麦冬-红景天-金荞麦”7味药共同组成的肺癌术后核心药组。结论：林洪生治疗肺癌术后患者以益气养阴为主，兼顾清热解毒，重视“固本清源”指导下“辨病-辨证-对症”三维一体综合诊治，促进康复、缓解不适症状，预防复发转移。

关键词：肺癌；中医治疗；固本清源；数据挖掘；林洪生；用药规律

Abstract：

Objective: To study the medication rules of LIN Hongsheng in treating postoperative lung cancer patients based on the "consolidating the foundation and clearing the source" method. Methods: Medical records of patients within one year after lung cancer surgery treated in the outpatient department by LIN Hongsheng at Guang'anmen Hospital, China Academy of Chinese Medical Sciences from January 1, 2008 to March 15, 2025 were collected. The Ancient and Modern Medical Case Cloud Platform was used to analyze the rules of high-frequency drugs, properties of Chinese medicines, and multi-herb correlation in the prescriptions. Results: A total of 151 postoperative lung cancer patients were included. The most frequent symptoms within 1 year after surgery were sleep disturbances (181 occurrences, 53.1%), cough (176 occurrences, 51.6%), shortness of breath (137 occurrences, 40.2%), fatigue (126 occurrences, 36.9%), and sweating (92 occurrences, 27.0%). The study involved 341 prescriptions, 116 kinds of Chinese herbs, with a total frequency of 6,038. High-frequency drugs included Hongjingtian (Rhodiolae Crenulatae Radix et Rhizoma), Baizhu (Atractylodis Macrocephalae Rhizoma), Tiandong (Asparagi Radix), Jinqiaomai (Fagopyri Dibotryis Rhizoma et Radix), etc., and the primary therapeutic effects of the prescribed herbs were tonifying deficiency and clearing heat. Combined with association rule analysis, cluster analysis and complex network analysis, the core drug group for postoperative lung cancer was concluded to be composed of 7 drugs: Huangqi (Astragali Radix), Fangfeng (Saposhnikoviae Radix), Baizhu (Atractylodis Macrocephalae Rhizoma), Tiandong (Asparagi Radix), Maidong (Ophiopogonis Radix), Hongjingtian (Rhodiolae Crenulatae Radix et Rhizoma) and Jinqiaomai (Fagopyri Dibotryis Rhizoma et Radix). Conclusion: LIN Hongsheng's treatment for postoperative lung cancer patients focuses on supplementing Qi and nourishing Yin, while also incorporating heat-clearing and detoxifying therapies. He attaches importance to the three-dimensional integrated diagnosis and treatment of "disease differentiation-syndrome differentiation-symptom management" under the guidance of "consolidating the foundation and clearing the source", so as to promote rehabilitation, relieve uncomfortable symptoms and prevent recurrence and metastasis.

Key words：lung cancer; traditional Chinese medicine treatment; consolidating the foundation and clearing the source; data mining; LIN Hongsheng; medication rules

发布时间：2025-12-31

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