温经止痛汤对青春期寒凝血瘀型痛经患者血清PGF2α、PGE2及子宫动脉血流动力学的影响*

作者：刘花妮，曹利萍，刘生玲，刘花荣

单位：榆林市中医医院，陕西 榆林 719000

引用：引用：刘花妮，曹利萍，刘生玲，刘花荣.温经止痛汤对青春期寒凝血瘀型痛经患者血清PGF2α、PGE2及子宫动脉血流动力学的影响[J].中医药导报,2025,31(12):138-142.

DOI：10.13862/j.cn43-1446/r.2025.12.022

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摘要：

目的：观察温经止痛汤对青春期寒凝血瘀型痛经患者血清前列腺素F2α（PGF2α）、前列腺素E2（PGE2）及子宫动脉血流动力学的影响。方法：选择2024年1—12月在我院接受治疗的120例青春期痛经患者，采用随机数字表法分为两组，每组各60例。观察组予温经止痛汤+布洛芬缓释胶囊治疗，对照组仅予布洛芬缓释胶囊治疗，均治疗3个月经周期，比较两组临床疗效，血清PGF2α、PGE2及子宫动脉血流动力学变化。结果：观察组总有效率为96.67%（58/60），显著高于对照组的78.33%（47/60），差异有统计学意义（P＜0.05）。两组患者血清PGF2α水平、痛经持续时间、视觉模拟评分（VAS）以及子宫动脉搏动指数（PI）和阻力指数（RI）均较治疗前降低（P＜0.05），而血清PGE2水平则升高（P＜0.05），且观察组患者上述指标的改善幅度均大于对照组（P＜0.05）。结论：温经止痛汤治疗青春期寒凝血瘀型痛经疗效确切，可调节血清PGF2α、PGE2水平，还可改善子宫动脉血流动力学，缩短痛经时间，减轻疼痛程度。

关键词：青春期痛经；寒凝血瘀型；温经止痛汤；前列腺素F2α；前列腺素E2；子宫动脉血流动力学

Abstract：

Objective: To observe the effects of Wenjing Zhitong Decoction on serum PGF2α, PGE2, and uterine artery hemodynamics in adolescent patients with dysmenorrhea of cold coagulation and blood stasis type. Methods: 120 adolescent dysmenorrhea patients treated from January to December 2024 were randomly divided into two groups, 60 cases in each. The observation group received Wenjing Zhitong Decoction plus ibuprofen sustained-release capsules; the control group received ibuprofen alone. Both groups were treated for 3 menstrual cycles. Clinical efficacy, serum PGF2α, PGE2 levels, and uterine artery hemodynamics were compared. Results: The total effective rate was 96.67% (58/60) in the observation group, significantly higher than 78.33% (47/60) in the control group (P<0.05). Serum PGF2α levels, dysmenorrhea duration, VAS scores, uterine artery PI and RI decreased in both groups after treatment (P<0.05), while PGE2 increased (P<0.05). Improvements were greater in the observation group (P<0.05). Conclusion: Wenjing Zhitong Decoction is effective for adolescent dysmenorrhea of cold coagulation and blood stasis type. It can regulate serum PGF2α and PGE2 levels, improve uterine artery hemodynamics, shorten dysmenorrhea duration, and reduce pain intensity.

Key words：adolescent dysmenorrhea; cold coagulation and blood stasis type; Wenjing Zhitong Decoction; PGF2α; PGE2; uterine artery hemodynamics

发布时间：2025-12-31

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