中医五行音乐对不孕症患者焦虑情绪及心率变异性的影响*

作者：董英辉1，李 慧1，戴芳芳1，赵晓丹1，王树松2，李 星1，郑 波1

单位：1.邢台市生殖医学质量控制中心/邢台市生殖医学重点实验室，河北 邢台 054001； 2.河北省计划生育科学技术研究院/河北省生殖医学重点实验室，河北 石家庄 050051

引用：引用：董英辉，李慧，戴芳芳，赵晓丹，王树松，李星，郑波.中医五行音乐对不孕症患者焦虑情绪及心率变异性的影响[J].中医药导报,2025,31(4):118-121,151.

DOI：10.13862/j.cn43-1446/r.2025.04.019

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摘要：

目的：探讨中医五行音乐对不孕症患者焦虑情绪及心率变异性（HRV）的影响。方法：采用焦虑自评量表（SAS）对体外受精-胚胎移植（IVF-ET）患者进行调查，筛选SAS评分≥50分且辨证为肝气郁结证或肾精亏虚证的患者228例，随机分为对照组（n=114例）和治疗组（n=114例）。自患者进入周期时，对照组患者按照常规诊疗进行；治疗组在对照组的基础上进行中医五行音乐治疗，每周3次，30 min/次。试验至取卵前一天结束。对比两组患者治疗前后焦虑自评量表（SAS）评分及HRV各指标的变化，以及聆听不同音乐调式HRV各指标的变化。结果：治疗后治疗组患者SDNN、RMSSD、TP、LF、HF均高于对照组（P<0.05），SAS评分、PSI低于对照组（P<0.05）；治疗后治疗组患者SDNN、TP高于治疗前（P<0.05），SAS评分、PSI低于治疗前（P<0.05）。聆听角音患者的PSI显著降低（P<0.05），TP和LF显著升高（P<0.05）；聆听羽音患者的RMSSD、HF均显著升高（P<0.05）。结论：中医五行音乐对缓解不孕症患者的焦虑情绪、提高心率变异性、改善自主神经系统的活性具有积极作用。

关键词：不孕症；IVF-ET；焦虑；中医五行音乐；心率变异性；音乐调式

Abstract：

Objective: To explore the effects of Five-Phase Music Therapy (FPMT), a traditional Chinese medicine (TCM) intervention, on anxiety and heart rate variability (HRV) in infertile patients. Methods: A total of 228 patients undergoing in vitro fertilization-embryo transfer (IVF-ET) with self-rating anxiety scale (SAS) scores≥50 and diagnosed with liver Qi stagnation pattern or kidney essence deficiency pattern were randomly divided into a control group (n=114) and a treatment group (n=114). The control group received routine clinical care, while the treatment group underwent additional FPMT (30 minutes per session, 3 sessions weekly) from cycle initiation until the day before oocyte retrieval. Outcomes included changes in SAS scores and HRV parameters [standard deviation of normal-to-normal intervals (SDNN), root mean square of successive differences (RMSSD), total power (TP), low-frequency power (LF), high-frequency power (HF), and physiological stress index (PSI)]. The effects of different musical modes [e.g., Jue (Wood phase) and Yu (Water phase)] on HRV were also analyzed. Results: Post-treatment, the treatment group exhibited significantly higher SDNN, RMSSD, TP, LF, and HF (P<0.05), and lower SAS scores and PSI (P<0.05) compared to the control group. Within the treatment group, SDNN and TP increased (P<0.05), while SAS and PSI decreased (P<0.05) post-intervention. Patients listening to Jue-mode music showed reduced PSI (P<0.05) and elevated TP and LF (P<0.05), whereas Yu-mode music listeners demonstrated increased RMSSD and HF (P<0.05). Conclusion: FPMT alleviates anxiety, enhances HRV, and improves autonomic nervous system activity in infertile patients, with modality-specific effects linked to musical phases.

Key words：infertility; IVF-ET; anxiety; Five-Phase music therapy; heart rate variability; musical modes

发布时间：2025-12-20

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