蒙药肋柱花化学成分、药理作用及临床应用研究进展*
作者：黎 龙，李晓磊，田景民，张慧文，王建业，李 骁
单位：内蒙古医科大学药学院，内蒙古 呼和浩特 010059
引用：引用：黎龙，李晓磊，田景民，张慧文，王建业，李骁.蒙药肋柱花化学成分、药理作用及临床应用研究进展[J].中医药导报,2025,31(4):102-108.
DOI：10.13862/j.cn43-1446/r.2025.04.016
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摘要：蒙药肋柱花为龙胆科植物辐状肋柱花的干燥全草，为蒙古族常用药用植物。肋柱花蒙名为哈比日根一地格达，具有抑“协日”、解热、疗伤、健胃等功效，主治胆痞、黄疸、“协日”热、肝胆热病等。整理近20年国内外有关文献，对肋柱花的化学成分、药理作用及临床应用情况，发现肋柱花中主要包括黄酮类、■酮类、环烯醚萜类、三萜类、木脂素类及脂肪酸类化合物。肋柱花提取物在抗肿瘤、保肝、抑菌等方面有较好的作用。此外肋柱花复方制剂的使用也受到了关注，尽管种类较少，但在一些特定疾病治疗中表现出显著的疗效。随着对肋柱花化学成分、药理活性及临床应用的深入探究，肋柱花及其复方制剂有望成为治疗肿瘤及肝胆疾病的特色民族药，进而为临床提供更多有效安全的治疗方案，为传统医药的传承与发展注入活力。
关键词：肋柱花；蒙药；化学成分；药理作用；临床应用；综述
Abstract：
Lomatogonium rotatum (Mongolian name: Habirigen-Yidagda), a dried whole herb of Lomatogonium rotatum (Gentianaceae), is a traditional Mongolian medicinal plant widely used to treat biliary disorders, jaundice, "Xieri" fever (a heat-related syndrome in Mongolian medicine), and hepatobiliary inflammatory diseases. It is recognized for its effects in inhibiting "Xieri" (a pathological heat concept), reducing fever, healing wounds, and improving digestion. Based on a comprehensive review of domestic and international literature over the past two decades, the chemical constituents of L. rotatum primarily include flavonoids, xanthones, iridoids, triterpenoids, lignans, and fatty acids. Extracts of L. rotatum exhibit notable pharmacological activities, including anticancer, hepatoprotective, and antibacterial effects. Furthermore, its compound preparations, though limited in variety, have shown significant therapeutic potential in specific diseases. With in-depth exploration of its chemical composition, pharmacological properties, and clinical applications, L. rotatum and its compound formulations are expected to become distinctive ethnic medicines for treating tumors and hepatobiliary diseases, offering safe and effective clinical solutions while invigorating the inheritance and development of traditional medicine.
Key words：Lomatogonium rotatum; Mongolian medicine; chemical constituents; pharmacological effects; clinical applications; review
发布时间：2025-12-20
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