壮医药线点灸联合拔罐对急性带状疱疹患者症状控制及血清神经激肽-1水平的影响*

作者：张 静，屠睿珏，施 欢

单位：上海市皮肤病医院，上海 200443

引用：引用：张静，屠睿珏，施欢.壮医药线点灸联合拔罐对急性带状疱疹患者症状控制及血清神经激肽-1水平的影响[J].中医药导报,2025,31(11):106-109,120.

DOI：10.13862/j.cn43-1446/r.2025.11.019

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摘要：

目的：探究壮医药线点灸联合拔罐对急性带状疱疹患者症状控制及血清神经激肽-1（NK-1）水平的影响。方法：选取2022年2月至2024年6月在本院治疗的急性带状疱疹患者94例，随机分为观察组（46例）和对照组（48例）。对照组给予壮医药线点灸治疗，观察组给予壮医药线点灸联合拔罐治疗。比较两组患者的临床疗效，采用视觉模拟评分法（VAS）、匹兹堡睡眠质量指数（PSQI）评估患者疼痛程度与睡眠质量，采用酶联免疫吸附测定（ELISA）法检测患者血清NK-1、P物质（SP）、β-内啡肽（β-EP）水平和炎症因子水平[白介素-10（IL-10）、IL-17、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）]，记录两组患者止疱时间、结痂时间、脱痂时间。结果：总有效率观察组为97.83%（45/46），高于对照组的83.33%（40/48），差异有统计学意义（P<0.05）；且与对照组相比，观察组止疱时间、结痂时间、脱痂时间明显缩短（P<0.05）。与治疗前相比，治疗后两组患者的VAS、PSQI评分及NK-1、SP、IL-10、IL-17、TNF-α、CRP水平均降低，且观察组各项指标均低于对照组（P<0.05）；治疗后两组患者的β-EP水平升高，且观察组高于对照组（P<0.05）。结论：壮医药线点灸联合拔罐治疗急性带状疱疹疗效显著，有助于快速改善症状，减轻炎症反应，降低NK-1水平，缓解疼痛。

关键词：急性带状疱疹；壮医药线点灸；拔罐；神经激肽-1；炎症因子

Abstract：

Objective: To investigate the effects of Zhuang medicine thread moxibustion combined with cupping therapy on symptom control and serum neurokinin-1 (NK-1) level in patients with acute herpes zoster. Methods: Ninety-four patients with acute herpes zoster treated in our hospital from February 2022 to June 2024 were randomly divided into an observation group (46 cases) and a control group (48 cases). The control group received Zhuang medicine thread moxibustion treatment, while the observation group received Zhuang medicine thread moxibustion combined with cupping therapy. The clinical efficacy of the two groups was observed. The Visual Analogue Scale (VAS) and Pittsburgh Sleep Quality Index (PSQI) were used to assess the degree of pain and sleep quality. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum levels of NK-1, substance P (SP), β-endorphin (β-EP), and inflammatory factors [interleukin-10 (IL-10), IL-17, tumor necrosis factor-α (TNF-α), C-reactive protein (CRP)]. The blistering cessation time, crust formation time, and crust removal time were recorded for both groups. Results: The total effective rate was 97.83%(45/46) in the observation group, which was significantly higher than 83.33% (40/48) in the control group, with the difference being statistically significant (P<0.05). Compared with the control group, the blistering cessation time, crust formation time, and crust removal time of the observation group were significantly shorter (P<0.05). Compared with before treatment, the VAS scores, PSQI scores, and levels of NK-1, SP, IL-10, IL-17, TNF-α, and CRP in both groups decreased after treatment, and these indicators in the observation group were lower than those in the control group (P<0.05). After treatment, the β-EP levels in both groups increased, and the level in the observation group was higher than that in the control group (P<0.05). Conclusion: Zhuang medicine thread moxibustion combined with cupping therapy has significant therapeutic effects on acute herpes zoster. It helps to quickly improve symptoms, alleviate inflammatory reactions, reduce NK-1 levels, and relieve pain.

Key words：acute herpes zoster; Zhuang medicine thread moxibustion; cupping; neurokinin-1; inflammatory factors

发布时间：2025-11-30

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