木犀草素抗乳腺癌的中西医融合机制——从清热解毒到靶向miR-21*

作者：伍 仙1，2，蒋 晶1，王 明1，李 玲2，冯传平1，3

单位：1.湖南中医药高等专科学校附属第一医院/湖南省直中医医院，湖南 株洲 412000； 2.湖南中医药大学，湖南 长沙 410208； 3.湖南中医药高等专科学校，湖南 株洲 412012

引用：引用：伍仙，蒋晶，王明，李玲，冯传平.木犀草素抗乳腺癌的中西医融合机制：从清热解毒到靶向miR-21[J].中医药导报,2026,32(5):124-130.

DOI：10.13862/j.cn43-1446/r.2026.05.020

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摘要：

从木犀草素的来源与基本特性、抗肿瘤机制两方面总结了木犀草素的抗肿瘤药理特性。研究表明，木犀草素可通过下调microRNA-21（miR-21），调控磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）、Wnt/β-连环蛋白（β-catenin）等关键信号通路，从而抑制乳腺癌细胞增殖并诱导其凋亡。从中医学理论角度看，木犀草素作为金银花、野菊花等清热解毒类中药的重要活性成分，其药理作用与中医病机治则高度契合。但目前关于木犀草素的临床转化研究仍相对薄弱，亟需系统深入探讨其作用机制与治疗潜力，以拓展乳腺癌中西医结合防治的新路径。

关键词：木犀草素；乳腺癌；微小RNA-21；清热解毒；中西医结合；综述

Abstract：

This article summarizes the anti-tumor pharmacological properties of luteolin from two aspects: its source and basic characteristics, and its anti-tumor mechanisms. Studies have shown that luteolin can inhibit breast cancer cell proliferation and induce apoptosis by downregulating microRNA-21 (miR-21) and regulating key signaling pathways such as PI3K/Akt and Wnt/β-catenin. From the perspective of traditional Chinese medicine (TCM) theory, luteolin, as an important active component of heat-clearing and detoxifying herbs such as 金银花 (Lonicera japonica) and 野菊花 (Chrysanthemum indicum), has pharmacological effects that are highly consistent with TCM pathogenesis and therapeutic principles. However, clinical translational research on luteolin remains relatively weak, and there is an urgent need for systematic and in-depth exploration of its mechanisms and therapeutic potential to expand new approaches for integrated traditional Chinese and western medicine in the prevention and treatment of breast cancer.

Key words：luteolin; breast cancer; microRNA-21; Qingre Jiedu; integrated traditional Chinese and western medicine; review

发布时间：2026-05-23

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