中医药调控TGF-β1/PI3K/Akt通路干预上皮间质转化研究进展*

作者：张昕欣1,2，张宇婧1,2，闫永彬1,2

单位：1.河南中医药大学儿科医学院，河南 郑州 450046； 2.河南中医药大学第一附属医院儿科医院，河南 郑州 450099

引用：引用：张昕欣，张宇婧，闫永彬.中医药调控TGF-β1/PI3K/Akt通路干预上皮间质转化研究进展[J].中医药导报,2026,32(5):114-123.

DOI：10.13862/j.cn43-1446/r.2026.05.019

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摘要：

挖掘转化生长因子-β1（TGF-β1）/磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）信号通路诱导上皮间质转化（EMT）发生的具体机制，剖析该机制在EMT相关疾病（纤维化疾病、肿瘤疾病和炎症性疾病）发生中的具体表现，综述中医药（中药复方、单味中药及中药活性成分等）调控TGF-β1/PI3K/Akt信号通路干预EMT治疗相关疾病的研究进展。TGF-β1/PI3K/Akt信号通路可协同调控EMT转录因子（SNAIL、SLUG等）及上皮/间质标志物（E-钙黏蛋白、N-钙黏蛋白等）表达而促进EMT进程；连翘苷A、薯蓣丸、罗欧咳祖帕复方等中药活性成分及复方可通过靶向抑制该信号通路抑制EMT发生、减少ECM沉积、改善组织纤维化、降低肿瘤细胞迁移侵袭、逆转耐药、减轻炎症反应而发挥治疗作用，延缓相关疾病进展。

关键词：上皮间质转化；中医药治疗；TGF-β1/PI3K/Akt信号通路；作用机制；综述

Abstract：

This article explores the specific mechanism by which the transforming growth factor-β1 (TGF-β1)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway induces epithelial-mesenchymal transition (EMT), analyzes the specific manifestations of this mechanism in the development of EMT-related diseases (fibrotic diseases, tumor diseases, and inflammatory diseases), and reviews the research progress of traditional Chinese medicine (including TCM compounds, single herbs, and active ingredients of TCM) in regulating the TGF-β1/PI3K/Akt signaling pathway to intervene in EMT-related diseases. The results show that the TGF-β1/PI3K/Akt signaling pathway can synergistically regulate the expression of EMT transcription factors (SNAIL, SLUG, etc.) and epithelial/mesenchymal markers (E-cadherin, N-cadherin, etc.) to promote the EMT process. Active ingredients and compounds of TCM, such as forsythiaside A, Shuyu Pills (薯蓣丸), and Luo'ouke Zupa Decoction (罗欧咳祖帕复方), can inhibit EMT, reduce extracellular matrix deposition, improve tissue fibrosis, reduce tumor cell migration and invasion, reverse drug resistance, and alleviate inflammatory responses by targeting this signaling pathway, thereby exerting therapeutic effects and delaying the progression of related diseases.

Key words：epithelial-mesenchymal transition; traditional Chinese medicine treatment; TGF-β1/PI3K/Akt signaling pathway; mechanism of action; review

发布时间：2026-05-23

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