大柴胡汤合左金丸储药罐联合井穴揿针治疗非糜烂性反流病的疗效及对情绪的影响*

作者：张 萍，徐陆周，游淑茹，王晶晶

单位：江苏省中医院，江苏 南京 210029

引用：引用：张萍，徐陆周，游淑茹，王晶晶.大柴胡汤合左金丸储药罐联合井穴揿针治疗非糜烂性反流病的疗效及情绪的影响[J].中医药导报,2026,32(5):109-113.

DOI：10.13862/j.cn43-1446/r.2026.05.018

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摘要：目的：探讨大柴胡汤合左金丸储药罐联合井穴揿针治疗肝胃郁热型非糜烂性反流病的疗效及对情绪的影响。方法：将120例肝胃郁热型非糜烂性反流病患者随机分为对照组和干预组，每组60例。对照组采用常规西医治疗及护理，干预组在对照组基础上予以大柴胡汤合左金丸储药罐联合井穴揿针治疗，均干预4周。比较两组患者中医证候评分、医院焦虑抑郁量表（HADS）评分、食管综合功能指标、胃食管反流病健康相关生存质量量表（GERD-HRQL）评分及总有效率。结果：干预组中医证候疗效总有效率为93.33%（56/60），高于对照组的81.67%（49/60），差异有统计学意义（P＜0.05）。干预后，两组患者各项中医证候评分、中医证候总评分、HADS评分、GERD-HRQL评分均低于干预前（P＜0.01），且干预组低于对照组（P＜0.01）；两组患者食管体部远端收缩积（DCI）、食管下括约肌压力（LESP）均高于干预前（P＜0.05或P＜0.01），且干预组高于对照组（P＜0.01）；两组患者反流次数少于干预前（P＜0.01），食管酸暴露时间短于干预前（P＜0.01），且干预组反流次数少于对照组（P＜0.01），食管酸暴露时间短于对照组（P＜0.01）。结论：大柴胡汤合左金丸储药罐联合井穴揿针可减轻肝胃郁热型非糜烂性反流病症状，改善患者情绪障碍及食管动力学指标，提高其生活质量和临床疗效。

关键词：非糜烂性反流病；胃食管反流病；肝胃郁热；情绪障碍；大柴胡汤合左金丸；经方储药罐；井穴；揿针

Abstract：

Objective: To investigate the efficacy of Dachaihu Decoction combined with Zuojin Pill herbal medicinal cupping plus well-point press needles in treating non-erosive reflux disease (NERD) of liver-stomach stagnant heat type and its effect on emotional state. Methods: A total of 120 patients with NERD of liver-stomach stagnant heat type were randomly divided into a control group and an intervention group, with 60 cases in each group. The control group received conventional Western medicine treatment and nursing, while the intervention group received additional Dachaihu Decoction combined with Zuojin Pill medicinal storage tank plus well-point pressing needle treatment for 4 weeks. TCM syndrome scores, Hospital Anxiety and Depression Scale (HADS) scores, comprehensive esophageal function indicators, Gastroesophageal Reflux Disease Health-Related Quality of Life Scale (GERD-HRQL) scores, and total effective rate were compared between the two groups. Results: The total effective rate of TCM syndrome efficacy in the intervention group was 93.33% (56/60), which was higher than 81.67% (49/60) in the control group, and the difference was statistically significant (P<0.05). After intervention, TCM syndrome scores, total TCM syndrome scores, Hospital Anxiety and Depression Scale (HADS) scores, and Hospital Anxiety and Depression Scale (HADS) scores in both groups decreased compared with before intervention (P<0.01), and the intervention group showed lower scores than the control group (P<0.01). After intervention, distal contraction integral (DCI) and lower esophageal sphincter pressure (LESP) in both groups increased compared with before intervention (P<0.05 or P<0.01), and the intervention group showed higher values than the control group (P<0.01). After intervention, the number of reflux episodes decreased and esophageal acid exposure time shortened in both groups (P<0.01), with the intervention group showing fewer reflux episodes and shorter acid exposure time than the control group (P<0.01). Conclusion: Dachaihu Decoction combined with Zuojin Pill herbal medicinal cupping plus well-point pressing needle can alleviate symptoms of NERD with liver-stomach stagnant heat type, improve emotional disorders and esophageal motility indicators, and enhance quality of life and clinical efficacy.

Key words：non-erosive reflux disease; gastroesophageal reflux disease; liver-stomach stagnant heat; emotional disorder; Dachaihu Decoction combined with Zuojin Pill; classical prescription herbal medicinal cupping; well acupoint; press needles

发布时间：2026-05-23

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