铁包金巴布膏治疗膝骨关节炎寒湿痹阻证的临床研究*

作者：韦臻韬1，蔡 萍2，欧 梁3，院一蔚1，张田田3，戎 宽3，熊逸啸1，匡建军2

单位：1.湖南中医药大学，湖南 长沙 410208； 2.湖南省中医药研究院，湖南 长沙 410013； 3.湖南省中医药研究院附属医院，湖南 长沙 410006

引用：引用：韦臻韬，蔡萍，欧梁，院一蔚，张田田，戎宽，熊逸啸，匡建军.铁包金巴布膏治疗膝骨关节炎寒湿痹阻证的临床研究[J].中医药导报,2026,32(4):96-101.

DOI：10.13862/j.cn43-1446/r.2026.04.015

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摘要：目的：探讨铁包金巴布膏治疗膝骨关节炎寒湿痹阻证的临床疗效。方法：将60例膝骨关节炎寒湿痹阻证患者按照随机数字表法分为治疗组和对照组，每组30例。两组均予基础治疗（硫酸氨基葡萄糖胶囊口服），对照组另予精制狗皮膏贴敷治疗，治疗组另予铁包金巴布膏贴敷治疗，两组均连续治疗4周。比较两组患者治疗前后西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分、疼痛视觉模拟（VAS）评分、膝关节活动度、中医证候评分及血清炎症因子[白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）]水平，并评价临床疗效和安全性。结果：治疗组临床疗效优于对照组（P＜0.05）；治疗后，两组患者WOMAC评分、VAS评分、中医证候评分及血清炎症因子（IL-1β、IL-6、TNF-α）水平均降低，膝关节活动度改善（P＜0.05），且治疗组患者WOMAC评分、VAS评分、中医证候评分及血清炎症因子（IL-1β、IL-6、TNF-α)水平均低于对照组（P＜0.05），膝关节活动度优于对照组（P＜0.05）。结论：铁包金巴布膏可有效改善膝骨关节炎寒湿痹阻证患者的关节功能与临床症状，降低血清炎症因子水平，且安全性良好。

关键词：膝骨关节炎；寒湿痹阻证；铁包金巴布膏；狗皮膏；炎症因子；临床研究

Abstract：

Objective: To investigate the clinical efficacy of Tiebaojin Cataplasm (铁包金巴布膏) in the treatment of knee osteoarthritis with cold-damp obstruction syndrome. Methods: Sixty patients with knee osteoarthritis of cold-damp obstruction syndrome were randomly divided into a treatment group and a control group, with 30 cases in each group. Both groups received basic treatment (oral administration of glucosamine sulfate capsules). On the basis of basic treatment, the control group was given external application of refined Goupi Gao (狗皮膏), while the treatment group was given external application of Tiebaojin Cataplasm, with a continuous treatment course of 4 weeks for both groups. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, visual analog scale (VAS) scores for pain, knee joint range of motion, traditional Chinese medicine (TCM) syndrome scores, and serum levels of inflammatory factors [interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] were compared between the two groups before and after treatment. The clinical efficacy and safety of the two therapies were also evaluated. Results: The clinical efficacy of the treatment group was significantly better than that of the control group (P<0.05). After treatment, the WOMAC scores, VAS scores, TCM syndrome scores and serum levels of inflammatory factors (IL-1β, IL-6, TNF-α) were all significantly decreased in both groups, and the knee joint range of motion was significantly improved (P<0.05). In addition, the above scores and serum inflammatory factor levels in the treatment group were significantly lower than those in the control group (P<0.05), and the improvement of knee joint range of motion in the treatment group was significantly better than that in the control group (P<0.05). Conclusion: Tiebaojin Cataplasm can effectively improve the joint function and clinical symptoms of patients with knee osteoarthritis of cold-damp obstruction syndrome, reduce the serum levels of inflammatory factors, with good clinical safety.

Key words：knee osteoarthritis; cold-damp obstruction syndrome; Tiebaojin Cataplasm; Goupi Gao; inflammatory factors; clinical study

发布时间：2026-04-26

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