基于超网络的西南地区治疗淋证献方用药特色*
作者：王晶爱1,2，李 兵1，张 卫1，田思玮1,3，张华敏1,2，李玮婕1,4，王嘉伦1，曾子玲1
单位：1.中国中医科学院中药研究所/道地药材品质保障与资源持续利用全国重点实验室，北京 100700； 2.中国中医科学院中医基础理论研究所，北京 100700； 3.中国中医科学院中医药数据中心，北京 100700； 4.国家药品监督管理局中医药研究与评价重点实验室，北京 100700
引用：引用：王晶爱，张卫，田思玮，张华敏，李玮婕，王嘉伦，李兵，曾子玲.基于超网络的西南地区治疗淋证献方用药特色[J].中医药导报,2026,32(3):179-184,219.
DOI：10.13862/j.cn43-1446/r.2026.03.028
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摘要：
目的：基于超网络对西南地区治疗淋证的地方用药规律进行挖掘，揭示其核心处方和常用地方药物，以期为中药资源开发与利用提供参考和借鉴。方法：以西南地区淋证献方为数据来源构建超网络，并进行拓扑结构分析，通过加权S-调和中心性提取核心子网，并对基于节点加权超度排名前20的药物子网络，采用Kumar算法划分功效社区。结果：筛选后，共纳入176首献方，包含中药370味；通过加权S-调和中心性得到3层核心子网，从中提炼出以八正散加减的核心组方，以及包含地区特色药物的加减方。基于前20的节点加权超度药物，识别出3个社区子网，发现治疗单纯热淋、血淋伴有石淋、热淋伴有石淋复合证型的3个基础方。结论：西南地区淋证献方的组方不仅包含了临床治疗淋证的常用中药，亦涵盖了目前临床较少使用的川谷根、阳雀花根、木槿根等地方中草药，为地方中草药的开发提供了新思路。
关键词：淋证；献方；地方中草药；西南地区；超网络；数据挖掘
Abstract：
Objective: To explore the regional medication patterns for treating stranguria in Southwest China based on hypernetwork, so as to reveal its core prescriptions and commonly used local herbs and provide references for the development and utilization of traditional Chinese medicine resources. Methods: A hypernetwork was constructed based on folk prescriptions for stranguria syndrome in Southwest China, and topological structure analysis was performed. The core subnetwork was extracted via weighted S-harmonic centrality, and the Kumar algorithm was used to divide efficacy communities for the top 20 herbal subnetworks ranked by node weighted hyperdegree. Result: After screening, a total of 176 folk prescriptions were included, involving 370 Chinese medicinal herbs. Three layers of core subnetworks were obtained using weighted S-harmonic centrality, from which the core prescription modified from Bazheng San (八正散) and modified prescriptions containing regional characteristic herbs were extracted. Based on the top 20 herbs by node weighted hyperdegree, three community subnetworks were identified, and three basic prescriptions were found for treating simple heat stranguria, blood stranguria complicated with stone stranguria, and heat stranguria complicated with stone stranguria respectively. Conclusion: The composition of the prescriptions for stranguria syndrome in Southwest China not only include commonly used Chinese medicinal herbs in clinical practice, but also cover local herbs rarely used in current clinical practice, such as Chuangugen (Coixlacryma-jobiL.var.moniliferWatt), Yangquehuagen (Caragana franchetiana Kom.), and Mujingen (Hibiscus syriacus L.), providing new ideas for the development of local Chinese herbal medicines.
Key words：stranguria syndrome; folk prescriptions; local Chinese herbal medicines; Southwest China; hypernetwork; data mining
发布时间：2026-03-28
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