基于隐结构模型与频繁项集的针灸治疗帕金森病非运动症状选穴规律*

作者：伊伸珑1，何启旺1，肖 蝶1，代诚博1，金小轩1，李亚楠1,2，万碧江1,2

单位：1.湖北中医药大学针灸骨伤学院，湖北 武汉 430060； 2.湖北时珍实验室，湖北 武汉 430060

引用：引用：伊伸珑，何启旺，肖蝶，代诚博，金小轩，李亚楠，万碧江.基于隐结构模型与频繁项集的针灸治疗帕金森病非运动症状的选穴规律[J].中医药导报,2026,32(3):166-172.

DOI：10.13862/j.cn43-1446/r.2026.03.026

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摘要：目的：探讨针灸治疗帕金森病非运动症状（PD-NMS）患者的辨证取穴规律，为临床治疗PD-NMS患者提供帮助。方法：采用系统性文献检索策略，查询中国知网（CNKI）、中国生物医学文献数据库（CBM）、维普中文期刊服务平台、万方数据知识服务平台（Wanfang Data）、PubMed、Embase、Web of Science等中英文数据库中有关针灸治疗PD-NMS的相关文献，提取症状、取穴处方信息构建医案数据库，采用隐结构模型、频繁项集分析等方法，分析针灸治疗PD-NMS的辨证取穴规律。检索时限均为建库至2025年2月28日。结果：系统检索中英文数据库，筛选针灸干预PD-NMS的临床文献46篇。在1 366份病历资料中提取71项症状体征、108个精准穴位定位点及114个穴位配伍方案构建结构化数据库，解析PD-NMS中医证型与取穴模式的对应规律。对症状、腧穴、证型进行频繁项集分析，挖掘出症状-腧穴频繁项集5项，包括五心烦热+腰酸+睡眠障碍+太冲等；证型-症状-腧穴频繁项集5项，包括肝肾阴虚证+五心烦热+腰酸+睡眠障碍+太冲+三阴交等。针灸治疗PD-NMS多以太冲、风池、合谷为主穴。结论：针灸治疗帕金森病非运动症状多以太冲、风池、合谷为主穴，配穴依据临床情况辨证取穴，此可为临床治疗帕金森病非运动症状提供参考。

关键词：帕金森病；非运动症状；针灸；隐结构模型；频繁项集；辨证选穴规律；数据挖掘；Apriori算法

Abstract：

Objective: To explore the patterns of syndrome differentiation and acupoint selection in acupuncture treatment for Parkinson's disease patients with non-motor symptoms (PD-NMS), so as to provide reference for the clinical treatment of PD-NMS patients. Methods: A systematic literature retrieval strategy was adopted to search relevant literatures on acupuncture for PD-NMS in Chinese and english databases including China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), VIP Chinese Journal Service Platfoum, Wanfang Data Knowledge Service Platform (Wanfang Data), PubMed, Embase and Web of Science from the establishment of databases to February 28, 2025. Information on symptoms and acupoint prescriptions was extracted to construct a medical case database. Latent structure model and frequent item set analysis were used to analyze the pattern of syndrome differentiation and acupoint selection in the acupuncture treatment for PD-NMS. Results: A total of 46 clinical literatures on acupuncture intervention for PD-NMS were screened after systematic retrieval of Chinese and English databases. A structured database was constructed by extracting 71 items of symptoms and signs, 108 precise acupoint locations and 114 acupoint compatibility schemes from 1366 medical records. The corresponding patterns of TCM syndromes and acupoint selection modes of PD-NMS were analyzed. Frequent itemset analysis was performed on symptoms, acupoints and syndromes, and 5 frequent itemsets of symptom-acupoint were obtained, including heat in the five centers + lumbar soreness + sleep disorder + Taichong (LR3), etc. Five frequent itemsets of syndrome-symptom-acupoint were identified, including liver-kidney Yin deficiency syndrome + heat in the five centers + lumbar soreness + sleep disorder + Taichong (LR3) + Sanyinjiao (SP6), etc. Taichong (LR3), Fengchi (GB20) and Hegu (LI4) were mostly used as the main acupoints in acupuncture for PD-NMS. Conclusion: Taichong (LR3), Fengchi (GB20) and Hegu (LI4) are mostly used as main acupoints in acupuncture for non-motor symptoms of Parkinson's disease, and adjunctive acupoints are selected based on clinical syndromes, which can provide reference for the clinical treatment of non-motor symptoms of Parkinson's disease.

Key words：Parkinson's disease; non-motor symptoms; acupuncture; latent structure model; frequent itemsets; patterns of syndrome differentiation and acupoint selection; data mining; Apriori algorithm

发布时间：2026-03-28

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