熟地黄治疗骨质疏松症机制研究进展*

作者：路 嘉，高斌礼，王跃翔，吕轶伦

单位：内蒙古医科大学附属医院，内蒙古 呼和浩特 010030

引用：引用：路嘉，高斌礼，王跃翔，吕轶伦.熟地黄治疗骨质疏松症机制研究进展[J].中医药导报,2026,32(3):153-158.

DOI：10.13862/j.cn43-1446/r.2026.03.024

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摘要：骨质疏松症（OP）是一种以骨量减少和骨微结构破坏为特征的退行性疾病，严重影响患者的生活质量。熟地黄为传统中药，具有补肾健脾、滋阴养血等功效，可增强免疫力，调控骨代谢平衡。本文综述了熟地黄治疗OP的机制。熟地黄可通过促进成骨细胞增殖与分化，增强骨髓间充质干细胞（BMMSC）的成骨向分化能力以增强骨形成；熟地黄可抑制破骨细胞活性及相关信号通路[如护骨因子（OPG）/NF-κB受体激活蛋白配体（RANKL）/NF-κB受体激活蛋白（RANK）]，减少骨吸收；熟地黄可调控Wnt/β-catenin、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）、沉默信息调节因子6（SIRT 6）/雌激素受体α（ERα）/Fas配体（FasL）等关键信号通路，以维持骨稳态。

关键词：骨质疏松症；熟地黄；骨形成；骨吸收；信号通路；网络药理学；综述

Abstract：

Osteoporosis (OP) is a degenerative disease characterized by reduced bone mass and deterioration of bone microarchitecture, significantly impacting patients' quality of life. Shudihuang (Rehmanniae Radix Praeparata), a traditional Chinese medicine, has the effects of tonifying the kidney, strengthening the spleen, nourishing yin, and enriching blood. It can enhance immunity and regulate bone metabolic balance. This article reviews the mechanisms of Shudihuang (Rehmanniae Radix Praeparata) in treating OP. Shudihuang (Rehmanniae Radix Praeparata) can enhance bone formation by promoting osteoblast proliferation and differentiation, and enhancing the osteogenic differentiation capacity of bone marrow mesenchymal stem cells (BMMSC). Shudihuang (Rehmanniae Radix Praeparata) can reduce bone resorption by inhibiting osteoclast activity and related signaling pathways [e.g., the osteoprotegerin (OPG)/receptor activator of NF-κB ligand (RANKL)/receptor activator of NF-κB (RANK) pathway]. Furthermore, Shudihuang (Rehmanniae Radix Praeparata) can regulate key signaling pathways such as Wnt/β-catenin, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), and silent information regulator 6 (SIRT6)/estrogen receptor α (ERα)/Fas ligand (FasL) to maintain bone homeostasis.

Key words：osteoporosis; Shudihuang (Rehmanniae Radix Praeparata); bone formation; bone resorption; signaling pathways; network pharmacology; review

发布时间：2026-03-28

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