中医药调控PI3K/Akt通路治疗类风湿关节炎骨破坏研究进展*

作者：邓 杰1，谷慧敏2，马俊福2，郭西昆1，李玉洁1

单位：1.河南中医药大学骨伤学院，河南 郑州 450046； 2.河南省中医院，河南 郑州 450002

引用：引用：邓杰，谷慧敏，马俊福，郭西昆，李玉洁.中医药调控PI3K/Akt通路治疗类风湿关节炎骨破坏研究进展[J].中医药导报,2026,32(3):147-152,172.

DOI：10.13862/j.cn43-1446/r.2026.03.023

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摘要：综述磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）信号通路在类风湿关节炎（RA）骨破坏中的研究现状，并总结中医药调控PI3K/Akt信号通路治疗RA骨破坏的研究进展。PI3K/Akt信号通路可通过调控炎症反应、破骨细胞分化、成纤维样滑膜细胞增殖及血管生成，在RA骨破坏中发挥作用。中医药可通过调控PI3K/Akt信号通路改善炎症反应，抑制破骨细胞、成纤维样滑膜细胞及血管生成，在RA骨破坏的治疗中表现出一定的优势。

关键词：类风湿关节炎；骨破坏；中医药；PI3K/Akt信号通路

Abstract：

This paper reviews the current research status of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway of bone destruction in rheumatoid arthritis (RA), and summarizes the research progress on the regulation of this pathway by traditional Chinese medicine (TCM) in treating RA bone destruction. The PI3K/Akt signaling pathway plays a role in RA bone destruction by regulating inflammatory responses, osteoclast differentiation, fibroblast-like synoviocyte proliferation, and angiogenesis. TCM can improve the inflammatory response, inhibit osteoclasts, fibroblast-like synoviocytes and angiogenesis by regulating the PI3K/Akt signaling pathway, demonstrating certain advantages in the treatment of bone destruction in RA.

Key words：rheumatoid arthritis; bone destruction; traditional Chinese medicine; PI3K/Akt signaling pathway

发布时间：2026-03-28

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