色氨酸及其代谢产物在动脉粥样硬化中的作用及中医药干预研究进展*

作者：周雨昕，徐逸宁，张淑洁，朱 尧，蒋卫民

单位：南京中医药大学附属医院，江苏 南京 210000

引用：引用：周雨昕，徐逸宁，张淑洁，朱尧，蒋卫民.色氨酸及其代谢产物在动脉粥样硬化中的作用及中医药干预研究进展[J].中医药导报,2025,31(5):152-158.

DOI：10.13862/j.cn43-1446/r.2025.05.027

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摘要：

动脉粥样硬化（AS）是众多心血管疾病的病理基础，其进展受到炎症反应的驱动，而色氨酸（Trp）代谢途径在调节炎症中起重要作用。Trp代谢途径包括5-羟色胺（5-HT）途径、犬尿氨酸（Kyn）途径及吲哚途径，其中部分代谢产物在AS的发生和发展中扮演着重要角色。Trp代谢产物不仅影响局部免疫反应，还可调节血管炎症、血栓形成等过程，成为心血管疾病潜在的生物标志物和治疗靶点。中医药作为一种多靶点治疗方式，逐渐成为调节Trp代谢、缓解心血管疾病的研究方向。通过综述Trp及其代谢产物在AS中的作用，评估中医药对Trp代谢途径的干预效果，认为未来通过中医药调控Trp代谢可能成为心血管疾病治疗的新策略。

关键词：动脉粥样硬化；心血管疾病；色氨酸代谢；炎症；综述

Abstract：

Atherosclerosis (AS) is the pathological basis of many cardiovascular diseases, and its progression is driven by inflammatory responses. The tryptophan (Trp) metabolic pathway plays a critical role in regulating inflammation. The Trp metabolic pathways include the 5-hydroxytryptamine (5-HT) pathway, the kynurenine (Kyn) pathway, and the indole pathway. Some of its metabolites play important roles in the occurrence and development of AS. Trp metabolites not only affect the local immune response but also regulate processes such as vascular inflammation and thrombosis, serving as potential biomarkers and therapeutic targets for cardiovascular diseases. As a multi-target therapeutic approach, traditional Chinese medicine (TCM) has gradually become a research direction for modulating Trp metabolism and alleviating cardiovascular diseases. By reviewing the role of Trp and its metabolites in AS and evaluating the intervention effect of TCM on the Trp metabolic pathway, it is believed that regulating Trp metabolism through TCM may become a new strategy for the treatment of cardiovascular diseases in the future.

Key words：atherosclerosis; cardiovascular diseases; tryptophan metabolism; inflammation; review

发布时间：2025-12-31

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