基于文献计量和知识图谱的中医药防治慢性疲劳综合征可视化分析*

作者：杨昭芸，杨 帅，赵广森，胡彧铭，程雅婕，吕沛宛

单位：河南中医药大学第二临床医学院，河南 郑州 450002

引用：引用：杨昭芸，杨帅，赵广森，胡彧铭，程雅婕，吕沛宛.基于文献计量和知识图谱的中医药防治慢性疲劳综合征可视化分析[J].中医药导报,2025,31(12):248-254.

DOI：10.13862/j.cn43-1446/r.2025.12.039

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摘要：目的：基于文献计量和知识图谱分析中医药防治慢性疲劳综合征（CFS）的研究现状和发展趋势，为进一步研究提供参考。方法：检索中国知网（CNKI）、万方数据知识服务平台（Wanfang Data）、维普中文期刊服务平台（CSTJ）和中国生物医学文献服务系统（SinoMed）从建库至2025年1月5日发表的中医药防治CFS相关文献，并根据纳入和排除标准进行筛选，用CiteSpace 6.4.R1(64-bit) Advanced进行年度发文量、作者及机构合作网络图谱、关键词知识图谱展示并分析。结果：共纳入2 299篇文献，年度发文量总体呈上升趋势；核心作者团队尚未形成（核心作者104人，发文占40.6%），主要研究机构集中于广州、成都、北京等地。可视化分析显示：高频应用的中医药疗法包括针刺/电针（215篇）、方药（如补中益气汤、逍遥散等）、艾灸（82篇）、推拿（100篇）等，近年隔姜灸、太极拳等特色疗法成为强突现热点；高频证型为肝郁脾虚型（66篇）、脾肾阳虚型及心脾两虚型，气虚质与阳虚质是主要体质关注点；肠道菌群是强突现指标，与免疫功能、下丘脑-垂体-肾上腺（HPA）轴等共同构成主要生物学机制研究方向；网络药理学与数据挖掘成为新兴研究手段；团队、机构间合作密度低（density=0.001 3），跨地域合作不足。结论：中医药防治CFS研究呈现疗法多样化、辨证精细化、机制深入化及方法现代化的趋势。未来研究应深化“证型-疗法-机制”关联研究，加强跨机构多中心合作以优化诊疗方案，推动现代化研究方法与传统经验的深度融合，提升临床疗效，促进形成科学、统一的诊疗规范。

关键词：慢性疲劳综合征；中医药；知识图谱；CiteSpace；可视化分析

Abstract：

Objective: To analyze the research status and development trends of traditional Chinese medicine (TCM) in the prevention and treatment of chronic fatigue syndrome (CFS) based on bibliometrics and knowledge graph, so as to provide a reference for further research. Methods: Literatures related to TCM prevention and treatment of CFS published from the establishment of databases to January 5, 2025 were retrieved from China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform (Wanfang Data), China Science and Technology Journal Database (CSTJ) and China Biomedical Literature Service System (SinoMed), and screened according to inclusion and exclusion criteria. CiteSpace 6.4.R1 (64-bit) Advanced was used to display and analyze the annual number of publications, author and institutional cooperation network maps, and keyword knowledge graphs. Results: A total of 2,299 literatures were included, and the annual number of publications showed an overall upward trend. The core author team had not yet been formed (104 core authors, accounting for 40.6% of total publications), and major research institutions were concentrated in Guangzhou, Chengdu, Beijing and other regions. Visual analysis showed that high-frequency TCM therapies included acupuncture/ electroacupuncture (215 papers), herbal prescriptions (such as Buzhong Yiqi Decoction (补中益气汤), Xiaoyao Powder (逍遥散), etc.), moxibustion (82 papers), tuina massage (100 papers), and etc. In recent years, characteristic therapies such as ginger-partitioned moxibustion and Tai Chi have emerged as strong research hotspots. High-frequency TCM syndrome patterns included liver depression and spleen deficiency (66 articles), spleen-kidney yang deficiency, and heart-spleen deficiency. Qi deficiency and Yang deficiency constitutions were the main focuses in constitution research. Intestinal flora was a strong burst indicator, which together with immune function and the Hypothalamic-Pituitany-Adrend (HPA) axis constituted the main research directions of biological mechanisms. Network pharmacology and data mining had become emerging research methods. The cooperation density between teams and institutions was low (density=0.0013), and cross-regional cooperation was insufficient. Conclusion: The research on TCM prevention and treatment of CFS presents the trends of diversified therapies, refined syndrome differentiation, in-depth mechanism research and modernized research methods. Future research should deepen the correlation research of "syndrome type-therapy-mechanism", strengthen cross-institutional and multi-center cooperation to optimize diagnosis and treatment schemes, promote the in-depth integration of modern research methods and traditional experience, improve clinical efficacy, and facilitate the formation of scientific and unified diagnosis and treatment standards.

Key words：chronic fatigue syndrome; traditional Chinese medicine; knowledge graph; CiteSpace; visual analysis

发布时间：2025-12-31

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