基于衰老相关分泌表型探讨天然化合物治疗膝骨关节炎的研究进展*

作者：王 鹏，王琛皓，王一恺，程绍磊，尤武林

单位：南京中医药大学附属无锡医院，江苏 无锡 214000

引用：引用：王鹏，王琛皓，王一恺，程绍磊，尤武林.基于衰老相关分泌表型探讨天然化合物治疗膝骨关节炎的研究进展[J].中医药导报,2025,31(12):203-210.

DOI：10.13862/j.cn43-1446/r.2025.12.033

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摘要：归纳和整理天然化合物通过调节衰老相关分泌表型治疗膝骨关节炎的作用机制。萜类、多酚类、黄酮类、生物碱类和苯丙素类天然化合物可通过多靶点、多层次调节衰老相关分泌表型关键组分（如细胞因子、生长因子、基质金属蛋白酶及其他生物活性分子），抑制软骨细胞衰老和关节软骨破坏，从而延缓膝骨关节炎的进展。目前研究存在大规模的临床试验验证匮乏、天然化合物生物利用度低、多组分协同作用机制不明及临床转化不足等挑战，具有广阔的探索空间。

关键词：膝骨关节炎；衰老相关分泌表型；细胞衰老；天然化合物；研究进展

Abstract：

This paper summarizes and sorts out the mechanisms of natural compounds in the treatment of knee osteoarthritis by regulating senescence-associated secretory phenotype (SASP). Natural compounds such as terpenoids, polyphenols, flavonoids, alkaloids and phenylpropanoids can regulate key components of SASP (including cytokines, growth factors, matrix metalloproteinases and other bioactive molecules) at multiple targets and levels, inhibit chondrocyte senescence and articular cartilage destruction, thereby delaying the progression of knee osteoarthritis. Current research faces challenges such as lack of large-scale clinical trial verification, low bioavailability of natural compounds, unclear synergistic mechanisms of multi-components, and insufficient clinical translation, which leaves broad space for further exploration.

Key words：knee osteoarthritis; senescence-associated secretory phenotype; cellular senescence; natural compounds; research progress

发布时间：2025-12-31

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