白藜芦醇治疗脊髓损伤的作用机制及转化研究进展*

作者：刘明昌1，李佳坤1，刘伟闯1，陈 欣2，刘建军2

单位：1.甘肃中医药大学，甘肃 兰州 730000； 2.甘肃中医药大学附属医院，甘肃 兰州 730000

引用：引用：刘明昌，李佳坤，刘伟闯，陈欣，刘建军.白藜芦醇治疗脊髓损伤的作用机制及转化研究进展[J].中医药导报,2025,31(12):174-179.

DOI：10.13862/j.cn43-1446/r.2025.12.028

PDF： 下载PDF

摘要：

脊髓损伤（SCI）作为严重的中枢神经系统创伤性疾病，其病理进程包括氧化应激、炎症级联反应、细胞程序性死亡等多重分子机制交互作用。白藜芦醇（Res）作为一种天然多酚类化合物，在SCI神经保护领域展现出重要的研究价值与应用潜力。本文系统综述了Res通过改善氧化应激、抑制炎症反应、调控自噬水平与细胞凋亡及减轻神经胶质瘢痕形成等方面作用机制发挥对SCI的神经保护作用，同时，针对Res在实际应用中存在的生物利用度低、靶向递送效率不足等临床转化瓶颈问题，深入探讨了纳米载药系统与生物材料的协同应用策略，旨在为Res治疗SCI的基础研究、新型药物开发及临床转化应用提供参考依据与研究思路。

关键词：脊髓损伤；白藜芦醇；氧化应激；炎症反应；程序性死亡；临床转化；综述

Abstract：

Spinal cord injury (SCI) is a severe traumatic central nervous system disease involving interactions among multiple molecular mechanisms such as oxidative stress, inflammatory cascades, and programmed cell death. Resveratrol (Res), a natural polyphenol, shows significant research value and application potential in SCI neuroprotection. This review systematically summarizes Res's neuroprotective mechanisms, including ameliorating oxidative stress, inhibiting inflammation, regulating autophagy and apoptosis, and reducing glial scar formation. It also discusses strategies like nano-drug delivery systems and biomaterials to address clinical translation challenges such as low bioavailability and insufficient targeted delivery. The aim is to provide references and ideas for basic research, new drug development, and clinical translation of Res in SCI treatment.

Key words：spinal cord injury; resveratrol; oxidative stress; inflammatory response; programmed cell death; clinical translation; review

发布时间：2025-12-31

点击量：6