基于层次分析法-批评矩阵法结合正交设计优选鼻通方提取工艺*

作者：王婷婷1，王红丽1，王悦悦1，罗燕燕1，赵爱军2，马琴国1

单位：1.甘肃省中医院，甘肃 兰州 730050； 2.甘肃中医药大学，甘肃 兰州 730000

引用：引用：王婷婷，王红丽，王悦悦，罗燕燕，赵爱军，马琴国.基于层次分析法-批评矩阵法结合正交设计优选鼻通方提取工艺[J].中医药导报,2025,31(12):110-114,148.

DOI：10.13862/j.cn43-1446/r.2025.12.017

PDF： 下载PDF

摘要：目的：优选鼻通方的提取工艺。方法：以料液比、提取温度、超声时间为考察因素，运用正交试验优化炒苍耳子油最佳提取工艺；以料液比、提取时间、提取次数为考察因素，运用层次分析法（AHP）-批评矩阵法（CRITIC）混合加权法计算毛蕊异黄酮葡萄糖苷、升麻素苷及浸膏得率的权重系数，并结合正交试验结果优选鼻通方的最佳水提工艺。结果：炒苍耳子油最佳提取工艺为提取溶剂无水乙醇，料液比1∶12（g/mL），提取温度70 ℃，超声时间50 min。AHP-CRITIC混合加权法优选最佳水提工艺为加8倍量水，提取3次，60 min/次。结论：AHP-CRITIC混合加权法可用于鼻通方提取工艺多指标的权重建立，并为后续鼻通丸新剂型的开发提供依据。

关键词：鼻通方；层次分析法-批评矩阵法；权重分析；正交试验；提取工艺

Abstract：

Objective: To optimize the extraction process of Bitong Prescription. Methods: Using solid-liquid ratio, extraction temperature, and ultrasonic time as factors, orthogonal experiment was applied to optimize the extraction process of fried Cangerzi (Xanthium sibiricum) oil. With solid-liquid ratio, extraction time, and extraction frequency as factors, the Analytic Hierarchy Process (AHP)-CRITIC mixed weighting method was used to calculate the weight coefficients of calycosin glucoside, prim-O-glucosylcimifugin, and extract yield. Combined with orthogonal experiment results, the optimal water extraction process for Bitong Prescription was determined. Results: The optimal extraction process for fried Xanthium sibiricum oil was: anhydrous ethanol as solvent, solid-liquid ratio of 1∶12 (g/mL), extraction temperature of 70 ℃, and ultrasonic time of 50 min. The AHP-CRITIC method indicated the optimal water extraction process as: adding 8 times the amount of water, extracting 3 times, 60 min each time. Conclusion: The AHP-CRITIC mixed weighting method can be used to establish weights for multiple indicators in the extraction process of Bitong Prescription and provides a basis for the development of new dosage forms such as Bitong Pills.

Key words：Bitong Prescription; AHP-CRITIC; weight analysis; orthogonal test; extraction process

发布时间：2025-12-31

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