基于CiteSpace软件可视化分析中医药联合PD-1/PD-L1研究热点及趋势*

作者：王梦琪，王 芹，焦丽静，杜怡曌，阿格尔，刘睿潮，韩 阳，周海伦，石振鹏，蒋 华，龚亚斌

单位：上海中医药大学附属岳阳中西医结合医院，上海 200437

引用：引用：王梦琪，王芹，焦丽静，杜怡曌，阿格尔，刘睿潮，韩阳，周海伦，石振鹏，蒋华，龚亚斌.基于CiteSpace软件可视化分析中医药联合PD-1/PD-L1研究热点及趋势[J].中医药导报,2025,31(11):136-145.

DOI：10.13862/j.cn43-1446/r.2025.11.025

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摘要：

目的：探讨中医药联合程序性死亡受体1/程序性死亡配体1（PD-1/PD-L1）的研究热点及研究前沿。方法：检索中国知网（CNKI）、万方数据知识服务平台（Wanfang Data）、维普中文期刊服务平台（CSTJ）、中国生物医学文献服务系统（SinoMed）、Web of Science核心合集、PubMed、Scopus等数据库自建库至2024年12月20日收录的中医药联合PD-1/PD-L1相关文献。运用Excel 2016分析发文趋势，运用CiteSpace文献计量软件，分析作者、机构、关键词，绘制作者合作图谱、机构合作图谱、关键词共现图谱、关键词突现图。结果：共纳入中文数据库文献201篇，英文数据库文献237篇。发文量呈逐年增加趋势，中医药联合PD-1/PD-L1相关文献最多的中英文期刊分别是《中医肿瘤学杂志》、Frontiers in Pharmacology，在中英文期刊发文最多的机构分别是广州中医药大学、天津中医药大学。关键词共现图谱和突现图显示，免疫治疗、肿瘤、肺癌、乙型肝炎、抗肿瘤活性、肿瘤微环境（TME）、肿瘤坏死因子（TNF）、CD8+T、磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）、信号转导和转录激活因子3（STAT3）、肿瘤蛋白53（P53）等是当前研究的热点。结论：中医药联合PD-1/PD-L1研究引起越来越多的关注，与中文文献不同的是，外文文献已经形成了稳定的核心作者群，研究热点包含了更多的细胞通路，英文文献质量较高，能够作为前沿研究的知识基础。该领域研究高产系列研究者较少，团体间外部合作松散，未来需要进一步加强作者、机构、地域合作，开展多中心前瞻性的临床研究。

关键词：PD-1/PD-L1；中医药；免疫；机制；文献计量学

Abstract：

Objective: To explore the research hotspots and frontiers of traditional Chinese medicine (TCM) combined with programmed death-1/programmed death-ligand 1 (PD-1/PD-L1). Methods: Relevant literatures on TCM combined with PD-1/PD-L1 published from the establishment of the databases to December 20, 2024 were retrieved from 6 databases, including China National Knowledge Infrastructure (CNKI）, Wanfang Data Knowledge Service Platform (Wanfang Data), China Science and Technology Journal Database (CSTJ), Chinese Biomedical Literature Service System (SinoMed), Web of Science Core Collection, PubMed, and Scopus. Excel 2016 was used to analyze the publication trend. CiteSpace bibliometric software was employed to analyze authors, institutions, and keywords, and to draw author collaboration maps, institutional collaboration maps, keyword co-occurrence maps, and keyword burst maps. Results: A total of 201 Chinese literatures and 237 english literatures were included. The number of publications showed an increasing trend year by year. The Chinese and english journals with the the largest number of literatures related to TCM combined with PD-1/PD-L1 were Journal of TCM Oncology and Frontiers in Pharmacology, respectively. The institutions with the most publications in Chinese and english journals were Guangzhou University of Chinese Medicine and Tianjin University of Chinese Medicine, respectively. Keyword co-occurrence maps and burst maps indicated that immunotherapy, tumor, lung cancer, hepatitis B, anti-tumor activity, tumor microenvironment (TME), tumor necrosis factor (TNF), CD8+ T cells, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), signal transducer and activator of transcription 3 (STAT3), and tumor protein 53 (P53) were the current research hotspots. Conclusion: Research on TCM combined with PD-1/PD-L1 has attracted increasing attention. Unlike Chinese literatures, english literatures have formed a stable core author group, with research hotspots covering more cellular pathways. English literatures are of higher quality and can serve as a knowledge base for frontier research. There are few high-yield researchers in this field, and external cooperation among teams is loose. In the future, it is necessary to further strengthen collaboration among authors, institutions, and regions, and carry out multi-center prospective clinical studies.

Key words：PD-1/PD-L1; traditional Chinese medicine; immunity; mechanism; bibliometrics

发布时间：2025-11-30

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