淫羊藿苷治疗结肠癌的作用机制研究进展*

作者：茅雯君，谭云艳，罗天平，闫家盼，陈凯瑞，左 飞

单位：南京中医药大学常州附属医院，江苏 常州 213000

引用：引用：茅雯君，谭云艳，罗天平，闫家盼，陈凯瑞，左飞.淫羊藿苷治疗结肠癌的作用机制研究进展[J].中医药导报,2025,31(11):131-135.

DOI：10.13862/j.cn43-1446/r.2025.11.024

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摘要：总结淫羊藿苷治疗结肠癌的作用机制。淫羊藿苷可通过调控相关蛋白，阻滞细胞周期从而抑制结肠癌细胞异常增殖；淫羊藿苷可通过调控促/抗凋亡蛋白的平衡诱导结肠癌细胞发生程序性死亡；淫羊藿苷可通过抑制肿瘤细胞的侵袭和迁移从而治疗结肠癌；淫羊藿苷可通过重构免疫细胞功能、重建T细胞免疫监视改善肿瘤免疫抑制微环境；淫羊藿苷与放化疗的协同使用，可提升化疗/放疗疗效。

关键词：结肠癌；淫羊藿苷；治疗机制；综述

Abstract：This article summarizes the mechanism of icariin in the treatment of colon cancer. Icariin can inhibit the abnormal proliferation of colon cancer cells by regulating related proteins and blocking the cell cycle; it can induce programmed cell death in colon cancer cells by regulating the balance of pro-apoptotic and anti-apoptotic proteins; it can treat colon cancer by inhibiting the invasion and migration of tumor cells; it can improve the tumor immunosuppressive microenvironment by reconstructing immune cell function and restoring T-cell immune surveillance; the combined use of icariin with radiotherapy and chemotherapy can enhance the efficacy of chemotherapy/radiotherapy.

Key words：colon cancer; icariin; therapeutic mechanism; review

发布时间：2025-11-30

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